Aromatase, aromatase inhibitors, and breast cancer
نویسندگان
چکیده
منابع مشابه
Aromatase inhibitors in breast cancer.
The development of aromatase inhibitors for breast cancer therapy is a result of successful translational research exploring the biochemical effects of different compounds in vivo. Studies assessing plasma oestrogen levels as well as in vivo aromatase inhibition have revealed a consistent difference with respect to biochemical efficacy between the third generation compounds (anastrozole, letroz...
متن کاملAromatase inhibitors in breast cancer.
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متن کاملAromatase inhibitors in breast cancer therapy.
Recent advances have been made in the hormonal treatment of breast cancer with the advent of third-generation aromatase inhibitors (anastrozole, letrozole, and exemestane). These newer agents have substantial antitumor activity and appear to be as effective as tamoxifen, with fewer adverse effects. Recent reports indicate that anastrozole is more effective than tamoxifen as adjuvant endocrine t...
متن کاملAromatase inhibitors in breast cancer: an update.
BACKGROUND Tamoxifen has been the endocrine treatment of choice for patients with breast cancer. The development of selective aromatase inhibitors has offered an alternative management approach for patients in whom a hormonal approach is indicated. METHODS The authors reviewed reports in which aromatase inhibitors were compared with tamoxifen for the treatment of metastatic disease, as well a...
متن کاملAromatase inhibitors in breast cancer: an overview.
We examined published reports on the use of aromatase inhibitors in postmenopausal patients with hormone receptor-positive breast cancer. Our data were obtained through a MEDLINE search of literature published in English. Current data indicate that aromatase inhibitors are equivalent or superior to tamoxifen as first-line therapy for metastatic breast cancer and as neoadjuvant treatment for pri...
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ژورنال
عنوان ژورنال: The Journal of Steroid Biochemistry and Molecular Biology
سال: 2011
ISSN: 0960-0760
DOI: 10.1016/j.jsbmb.2011.02.001